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"Any development that genuinely results in more choices becoming available for the more than 1 billion men and women who smoke today and moves the world closer to eliminating the cigarette should be applauded," he said.

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These efficiency improvements are crucial as plain packaging mandates erode brand-driven pricing power, pushing manufacturers to focus on cost optimization

Cul8, similar to Cul1, acts as a scaffold that binds Skp1 at its N-terminus and Fbxw8 at its C-terminus

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